In4Derm
Now Tay Therapeutics
Client
In4Derm
Type
Clinical-Stage
Location
Toronto, Canada
The Challenge
Promising UK-based spin-out in need of customized assays to demonstrate efficacy of lead preclinical candidates for dermatology indications.
The Solution
Dalriada’s Turn-Key™ Approach
Conducted an extensive literature search
- Identified potential and alternative proof-of-concept approaches.
- Identified clinically relevant benchmarks.
- Identified appropriate biomarkers to confirm MOA and benchmarks against competitive molecules and programs.
Developed, validated, and delivered a customized cellular assay.
The Impact
Resulting in a successful outcome…
- Validated the mechanism of action and demonstrated improved cellular efficacy versus a marketed competitor within a 2½-month program.
Dalriada’s expert biology team rapidly designed and delivered a bespoke novel primary cell assay system, with multiple inflammatory readouts, that allowed us to effectively screen several candidate compounds and significantly advance our target validation efforts towards our development of next generation therapies in skin diseases.