{"id":1256,"date":"2022-09-23T11:16:50","date_gmt":"2022-09-23T15:16:50","guid":{"rendered":"https:\/\/dalriadatx.com\/?page_id=1256"},"modified":"2024-04-07T16:00:30","modified_gmt":"2024-04-07T20:00:30","slug":"lead-optimization","status":"publish","type":"page","link":"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/lead-optimization\/","title":{"rendered":"Lead Optimization"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1256\" class=\"elementor elementor-1256\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"has_ma_el_bg_slider elementor-section elementor-top-section elementor-element elementor-element-8087714 elementor-section-height-min-height elementor-section-items-stretch elementor-section-content-middle elementor-section-boxed elementor-section-height-default jltma-glass-effect-no\" data-id=\"8087714\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-4792fdb jltma-glass-effect-no\" data-id=\"4792fdb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0e6ef59 jltma-glass-effect-no elementor-widget elementor-widget-spacer\" data-id=\"0e6ef59\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 26-03-2024 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-con{--container-widget-width:100%}.e-con-inner>.elementor-widget-spacer,.e-con>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));--align-self:var(--container-widget-align-self,initial);--flex-shrink:0}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container,.e-con>.elementor-widget-spacer>.elementor-widget-container{height:100%;width:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty,.e-con>.elementor-widget-spacer.elementor-widget-empty{position:relative;min-height:22px;min-width:22px}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon,.e-con>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon{position:absolute;top:0;bottom:0;left:0;right:0;margin:auto;padding:0;width:22px;height:22px}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-88c15d8 jltma-glass-effect-no\" data-id=\"88c15d8\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-97cf722 elementor-widget elementor-widget-heading\" data-id=\"97cf722\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 26-03-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">Concept to PDC Discovery Programs<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_ma_el_bg_slider elementor-section elementor-top-section elementor-element elementor-element-bab7e83 elementor-section-boxed elementor-section-height-default elementor-section-height-default jltma-glass-effect-no\" data-id=\"bab7e83\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-4d0a2c8 jltma-glass-effect-no\" data-id=\"4d0a2c8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"has_ma_el_bg_slider elementor-section elementor-inner-section elementor-element elementor-element-d639947 elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default jltma-glass-effect-no\" data-id=\"d639947\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-cb96b2c jltma-glass-effect-no\" data-id=\"cb96b2c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b880094 jltma-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"b880094\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Drug Discovery Services<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5d9bfc5 dalriada-side-menu elementor-nav-menu__text-align-aside jltma-glass-effect-no elementor-widget elementor-widget-nav-menu\" data-id=\"5d9bfc5\" data-element_type=\"widget\" data-settings=\"{&quot;layout&quot;:&quot;dropdown&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;i class=\\&quot;fas fa-angle-down\\&quot;&gt;&lt;\\\/i&gt;&quot;,&quot;library&quot;:&quot;fa-solid&quot;}}\" data-widget_type=\"nav-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<link rel=\"stylesheet\" href=\"https:\/\/dalriadatx.com\/wp-content\/plugins\/elementor-pro\/assets\/css\/widget-nav-menu.min.css\">\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-5d9bfc5\" class=\"elementor-nav-menu\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-1243\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/\" class=\"elementor-item\" tabindex=\"-1\">Concept to PDC  Discovery Programs<\/a>\n<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1245\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/target-validation\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Target Validation<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1244\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/hit-identification\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Hit Identification<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1263\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/hit-to-lead\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Hit to Lead<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1264\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/lead-optimization\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Lead Optimization<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2161\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/covalent-programs\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Covalent Programs<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2155\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/degrader-programs\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Degrader Programs<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2160\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/cannabinoid-programs\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Cannabinoid Programs<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-4092\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/psychedelic-programs\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Psychedelic Programs<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2156\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/nce-ip-creation-and-expansion\/\" class=\"elementor-sub-item\" tabindex=\"-1\">NCE IP Creation and Expansion<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2157\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/platform-technologies\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Platform Technologies<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2158\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/fast-follower\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Fast-Follower<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2159\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/therapeutic-areas\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Therapeutic Areas<\/a><\/li>\n<\/ul>\n<\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-581\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-strategy\/\" class=\"elementor-item\" tabindex=\"-1\">Turn-Key Discovery Strategy<\/a>\n<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2163\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-strategy\/program-design-execution\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Program Design &#038; Execution<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2172\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-strategy\/medicinal-chemistry\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Medicinal Chemistry<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2167\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-strategy\/in-vitro-pharmacology\/\" class=\"elementor-sub-item\" tabindex=\"-1\"><em>In Vitro<\/em> Pharmacology<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2171\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-strategy\/adme-and-dmpk\/\" class=\"elementor-sub-item\" tabindex=\"-1\">ADME and DMPK<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2168\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-strategy\/in-vivo-pharmacology\/\" class=\"elementor-sub-item\" tabindex=\"-1\"><em>In Vivo<\/em> Pharmacology<\/a><\/li>\n<\/ul>\n<\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-2173\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-management\/\" class=\"elementor-item\" tabindex=\"-1\">Turn-Key Discovery Management<\/a>\n<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2174\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-management\/program-management\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Program Management<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2178\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-management\/sub-contracting-management\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Sub-Contracting Management<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2175\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-management\/controlled-substances\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Controlled Substances<\/a><\/li>\n<\/ul>\n<\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-2179\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/\" class=\"elementor-item\" tabindex=\"-1\">Turn-Key Discovery Labs<\/a>\n<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-4087\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/chemistry\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Chemistry<\/a>\n\t<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2197\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/chemistry\/medicinal-chemistry\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Medicinal Chemistry<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2196\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/chemistry\/synthetic-chemistry\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Synthetic Chemistry<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2180\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/chemistry\/analytical-chemistry\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Analytical Chemistry<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-4091\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/in-vitro-biology\/\" class=\"elementor-sub-item\" tabindex=\"-1\"><em>In Vitro<\/em> Biology<\/a>\n\t<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2181\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/in-vitro-biology\/cell-and-molecular-biology\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Cell and Molecular Biology<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2195\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/in-vitro-biology\/protein-production\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Protein Production<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2194\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/in-vitro-biology\/biochemical-and-biophysical-assays\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Biochemical and Biophysical Assays<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2193\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/in-vitro-biology\/crystallography\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Crystallography<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-4084\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-strategy\/in-vitro-pharmacology\/ms-based-protein-assays\/\" class=\"elementor-sub-item\" tabindex=\"-1\">MS-Based Protein Assays<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-4086\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/dmpk\/\" class=\"elementor-sub-item\" tabindex=\"-1\">DMPK<\/a>\n\t<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2182\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/dmpk\/in-vitro-admet\/\" class=\"elementor-sub-item\" tabindex=\"-1\"><em>In Vitro<\/em> ADME(T)<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2184\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/dmpk\/in-vivo-dmpk\/\" class=\"elementor-sub-item\" tabindex=\"-1\"><em>In-Vivo<\/em> DMPK<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-4088\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/cadd\/\" class=\"elementor-sub-item\" tabindex=\"-1\">CADD<\/a>\n\t<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2185\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/cadd\/docking\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Docking<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2187\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/cadd\/model-development\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Model Development<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2186\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/cadd\/in-silico-adme\/\" class=\"elementor-sub-item\" tabindex=\"-1\"><em>In Silico<\/em> ADME(T)<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-4085\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/proteomics\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Proteomics<\/a>\n\t<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2191\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/proteomics\/whole-proteome-profiling\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Whole-Proteome Profiling<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2190\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/proteomics\/chemoproteomics\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Chemoproteomics<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-4089\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/custom-assays\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Custom Assays<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-4090\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/biomarker-analysis\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Biomarker Analysis<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eef3441 jltma-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"eef3441\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">&nbsp;<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7bdcd547 jltma-glass-effect-no\" data-id=\"7bdcd547\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5a19388 jltma-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"5a19388\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Lead Optimization<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4cec1f4 jltma-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"4cec1f4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 26-03-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Lead optimization involves converting a lead series to a pre-clinical candidate. This multiparameter optimization exercise involves fine-tuning the lead structures and drug-like properties to match the desired target product profile.<\/p><p>This design-make-test-analyze (DMTA) process requires both medicinal and computational design strategies, the use of efficient chemical synthesis and pharmacokinetic, pharmacodynamic and safety profile optimization. Where appropriate, structural biology, CADD, cell biology and proteomics are among the tools used to improve understanding of the potency, selectivity, and mechanisms of action.<\/p><p>At Dalriada, our focus is on establishing and implementing the appropriate screening cascade and selection criteria, and we are committed to delivering the fastest DMTA cycles in the industry, required for rapid decision-making during the hit-to-lead phase of any project. Our discovery scientists at Dalriada, with over 300 years combined industry experience, have a strong track record of delivering preclinical candidates across a variety of therapeutic areas, with a number of these programs advancing to the clinic.<\/p><p>With expansive capabilities in<a href=\"\/turn-key-discovery-labs\/chemistry\/\"><strong>\u00a0chemistry<\/strong><\/a><strong>,\u00a0<\/strong><a href=\"\/turn-key-discovery-labs\/in-vitro-biology\/\"><strong><em>in vitro<\/em><\/strong><strong> biology<\/strong><\/a><strong>,\u00a0<\/strong><a href=\"\/turn-key-discovery-strategy\/structural-biology\/\"><strong>structural biology<\/strong><\/a><strong>,\u00a0<\/strong><a href=\"\/turn-key-discovery-labs\/adme\/\"><strong>ADME<\/strong><\/a><strong>,\u00a0<\/strong><a href=\"\/turn-key-discovery-labs\/cadd\/\"><strong>CADD<\/strong><\/a>, and\u00a0<a href=\"\/turn-key-discovery-labs\/proteomics\/\"><strong>proteomics<\/strong><\/a><strong>,<\/strong>\u00a0Dalriada Discovery Labs can experimentally support most complex hit to lead programs. Our\u00a0<a href=\"\/turn-key-discovery-strategy\/\"><strong>Discovery Strategy<\/strong><\/a>\u00a0team will support the design and oversight of the program to be conducted within\u00a0<a href=\"\/turn-key-discovery-labs\/\"><strong>Discovery Labs<\/strong><\/a>\u00a0or sub-contracted, if required, via\u00a0<a href=\"\/turn-key-discovery-management\/\"><strong>Discovery Management<\/strong><\/a><strong>.<\/strong><\/p><p><a href=\"\/turn-key-model\/\"><strong>Learn more about our Turn-Key model here<\/strong><\/a>.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Concept to PDC Discovery Programs Drug Discovery Services &nbsp; Lead Optimization Lead optimization involves converting a lead series to a pre-clinical candidate. This multiparameter optimization exercise involves fine-tuning the lead structures and drug-like properties to match the desired target product profile. This design-make-test-analyze (DMTA) process requires both medicinal and computational design strategies, the use of [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":1233,"menu_order":45,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"folder":[],"_links":{"self":[{"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/pages\/1256"}],"collection":[{"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/comments?post=1256"}],"version-history":[{"count":4,"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/pages\/1256\/revisions"}],"predecessor-version":[{"id":7743,"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/pages\/1256\/revisions\/7743"}],"up":[{"embeddable":true,"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/pages\/1233"}],"wp:attachment":[{"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/media?parent=1256"}],"wp:term":[{"taxonomy":"folder","embeddable":true,"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/folder?post=1256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}