{"id":1248,"date":"2022-09-23T11:14:45","date_gmt":"2022-09-23T15:14:45","guid":{"rendered":"https:\/\/dalriadatx.com\/?page_id=1248"},"modified":"2024-04-07T15:54:23","modified_gmt":"2024-04-07T19:54:23","slug":"hit-to-lead","status":"publish","type":"page","link":"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/hit-to-lead\/","title":{"rendered":"Hit to Lead"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1248\" class=\"elementor elementor-1248\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"has_ma_el_bg_slider elementor-section elementor-top-section elementor-element elementor-element-609dadc elementor-section-height-min-height elementor-section-items-stretch elementor-section-content-middle elementor-section-boxed elementor-section-height-default jltma-glass-effect-no\" data-id=\"609dadc\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-19f72b4 jltma-glass-effect-no\" data-id=\"19f72b4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6274343 jltma-glass-effect-no elementor-widget elementor-widget-spacer\" data-id=\"6274343\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 26-03-2024 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-con{--container-widget-width:100%}.e-con-inner>.elementor-widget-spacer,.e-con>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));--align-self:var(--container-widget-align-self,initial);--flex-shrink:0}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container,.e-con>.elementor-widget-spacer>.elementor-widget-container{height:100%;width:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty,.e-con>.elementor-widget-spacer.elementor-widget-empty{position:relative;min-height:22px;min-width:22px}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon,.e-con>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon{position:absolute;top:0;bottom:0;left:0;right:0;margin:auto;padding:0;width:22px;height:22px}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-29ad34a jltma-glass-effect-no\" data-id=\"29ad34a\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2bcf46c elementor-widget elementor-widget-heading\" data-id=\"2bcf46c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 26-03-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">Concept to PDC Discovery Programs<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_ma_el_bg_slider elementor-section elementor-top-section elementor-element elementor-element-bab7e83 elementor-section-boxed elementor-section-height-default elementor-section-height-default jltma-glass-effect-no\" data-id=\"bab7e83\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-4d0a2c8 jltma-glass-effect-no\" data-id=\"4d0a2c8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"has_ma_el_bg_slider elementor-section elementor-inner-section elementor-element elementor-element-8bcdfc9 elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default jltma-glass-effect-no\" data-id=\"8bcdfc9\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-92a1ade jltma-glass-effect-no\" data-id=\"92a1ade\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a0d82b7 jltma-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"a0d82b7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Drug Discovery Services<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1648d44 dalriada-side-menu elementor-nav-menu__text-align-aside jltma-glass-effect-no elementor-widget elementor-widget-nav-menu\" data-id=\"1648d44\" data-element_type=\"widget\" data-settings=\"{&quot;layout&quot;:&quot;dropdown&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;i class=\\&quot;fas fa-angle-down\\&quot;&gt;&lt;\\\/i&gt;&quot;,&quot;library&quot;:&quot;fa-solid&quot;}}\" data-widget_type=\"nav-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<link rel=\"stylesheet\" href=\"https:\/\/dalriadatx.com\/wp-content\/plugins\/elementor-pro\/assets\/css\/widget-nav-menu.min.css\">\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-1648d44\" class=\"elementor-nav-menu\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-1243\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/\" class=\"elementor-item\" tabindex=\"-1\">Concept to PDC  Discovery Programs<\/a>\n<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1245\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/target-validation\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Target Validation<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1244\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/hit-identification\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Hit Identification<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1263\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/hit-to-lead\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Hit to Lead<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1264\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/lead-optimization\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Lead Optimization<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2161\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/covalent-programs\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Covalent Programs<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2155\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/degrader-programs\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Degrader Programs<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2160\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/cannabinoid-programs\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Cannabinoid Programs<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-4092\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/psychedelic-programs\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Psychedelic Programs<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2156\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/nce-ip-creation-and-expansion\/\" class=\"elementor-sub-item\" tabindex=\"-1\">NCE IP Creation and Expansion<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2157\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/platform-technologies\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Platform Technologies<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2158\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/fast-follower\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Fast-Follower<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2159\"><a href=\"https:\/\/dalriadatx.com\/concept-to-pdc-discovery-programs\/therapeutic-areas\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Therapeutic Areas<\/a><\/li>\n<\/ul>\n<\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-581\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-strategy\/\" class=\"elementor-item\" tabindex=\"-1\">Turn-Key Discovery Strategy<\/a>\n<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2163\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-strategy\/program-design-execution\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Program Design &#038; Execution<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2172\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-strategy\/medicinal-chemistry\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Medicinal Chemistry<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2167\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-strategy\/in-vitro-pharmacology\/\" class=\"elementor-sub-item\" tabindex=\"-1\"><em>In Vitro<\/em> Pharmacology<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2171\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-strategy\/adme-and-dmpk\/\" class=\"elementor-sub-item\" tabindex=\"-1\">ADME and DMPK<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2168\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-strategy\/in-vivo-pharmacology\/\" class=\"elementor-sub-item\" tabindex=\"-1\"><em>In Vivo<\/em> Pharmacology<\/a><\/li>\n<\/ul>\n<\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-2173\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-management\/\" class=\"elementor-item\" tabindex=\"-1\">Turn-Key Discovery Management<\/a>\n<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2174\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-management\/program-management\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Program Management<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2178\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-management\/sub-contracting-management\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Sub-Contracting Management<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2175\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-management\/controlled-substances\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Controlled Substances<\/a><\/li>\n<\/ul>\n<\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-2179\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/\" class=\"elementor-item\" tabindex=\"-1\">Turn-Key Discovery Labs<\/a>\n<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-4087\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/chemistry\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Chemistry<\/a>\n\t<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2197\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/chemistry\/medicinal-chemistry\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Medicinal Chemistry<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2196\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/chemistry\/synthetic-chemistry\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Synthetic Chemistry<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2180\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/chemistry\/analytical-chemistry\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Analytical Chemistry<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-4091\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/in-vitro-biology\/\" class=\"elementor-sub-item\" tabindex=\"-1\"><em>In Vitro<\/em> Biology<\/a>\n\t<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2181\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/in-vitro-biology\/cell-and-molecular-biology\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Cell and Molecular Biology<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2195\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/in-vitro-biology\/protein-production\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Protein Production<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2194\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/in-vitro-biology\/biochemical-and-biophysical-assays\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Biochemical and Biophysical Assays<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2193\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/in-vitro-biology\/crystallography\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Crystallography<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-4084\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-strategy\/in-vitro-pharmacology\/ms-based-protein-assays\/\" class=\"elementor-sub-item\" tabindex=\"-1\">MS-Based Protein Assays<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-4086\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/dmpk\/\" class=\"elementor-sub-item\" tabindex=\"-1\">DMPK<\/a>\n\t<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2182\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/dmpk\/in-vitro-admet\/\" class=\"elementor-sub-item\" tabindex=\"-1\"><em>In Vitro<\/em> ADME(T)<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2184\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/dmpk\/in-vivo-dmpk\/\" class=\"elementor-sub-item\" tabindex=\"-1\"><em>In-Vivo<\/em> DMPK<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-4088\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/cadd\/\" class=\"elementor-sub-item\" tabindex=\"-1\">CADD<\/a>\n\t<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2185\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/cadd\/docking\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Docking<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2187\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/cadd\/model-development\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Model Development<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2186\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/cadd\/in-silico-adme\/\" class=\"elementor-sub-item\" tabindex=\"-1\"><em>In Silico<\/em> ADME(T)<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-4085\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/proteomics\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Proteomics<\/a>\n\t<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2191\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/proteomics\/whole-proteome-profiling\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Whole-Proteome Profiling<\/a><\/li>\n\t\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-2190\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/proteomics\/chemoproteomics\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Chemoproteomics<\/a><\/li>\n\t<\/ul>\n<\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-4089\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/custom-assays\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Custom Assays<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-4090\"><a href=\"https:\/\/dalriadatx.com\/turn-key-discovery-labs\/biomarker-analysis\/\" class=\"elementor-sub-item\" tabindex=\"-1\">Biomarker Analysis<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-be419e1 jltma-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"be419e1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">&nbsp;<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_ma_el_bg_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7bdcd547 jltma-glass-effect-no\" data-id=\"7bdcd547\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a4c7ff5 jltma-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"a4c7ff5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Hit to Lead<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4cec1f4 jltma-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"4cec1f4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 26-03-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Hit to Lead (H2L) is the process of optimizing validated hits to demonstrate they have the potential to become lead compounds and eventually a pre-clinical candidate. A series suitable to progress into lead optimization should demonstrate:<\/p>\n<ul>\n<li>The compound is clearly on target and elicits the desired\/expected effects <em>in vitro<\/em>, including counter-screens.<\/li>\n<li>Productive and tractable structure-activity relationships (SAR) across potency assays and structure-property relationships across DMPK assays.<\/li>\n<li>Preliminary <em>in vitro<\/em> safety assessed, and substantial issues identified.<\/li>\n<li>Suitable <em>in vivo<\/em> pharmacokinetic data in disease model species.<\/li>\n<li>Initial pharmacodynamic effects in a relevant <em>in vivo<\/em> disease model.<\/li>\n<\/ul>\n<p><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var( --e-global-typography-text-font-size ); font-style: var( --e-global-typography-text-font-style ); letter-spacing: var( --e-global-typography-text-letter-spacing ); text-transform: var( --e-global-typography-text-text-transform ); background-color: var( --e-global-color-c696dce );\"><br>At Dalriada, our focus is on establishing and implementing the appropriate screening cascade and selection criteria. We are committed to fastest in the industry design-make-test-analyze cycles, required for rapid decision making during the hit to lead phase of any project. Our discovery scientists at Dalriada with over 300 years combined industry drug discovery experience have a strong track record of delivering on hit-to-lead programs across a variety of therapeutic areas, with a number of programs advancing to the clinic.<\/span><br><\/p>\n<p>With expansive capabilities in&nbsp;<a href=\"\/turn-key-discovery-labs\/chemistry\/\"><strong>chemistry<\/strong><\/a><strong>,&nbsp;<\/strong><a href=\"\/turn-key-discovery-labs\/in-vitro-biology\/\"><strong><em>in vitro<\/em><\/strong><strong> biology<\/strong><\/a><strong>,&nbsp;<\/strong><a href=\"\/turn-key-discovery-strategy\/structural-biology\/\"><strong>structural biology<\/strong><\/a><strong>,&nbsp;<\/strong><a href=\"\/turn-key-discovery-labs\/adme\/\"><strong>ADME<\/strong><\/a><strong>,&nbsp;<\/strong><a href=\"\/turn-key-discovery-labs\/cadd\/\"><strong>CADD<\/strong><\/a>, and custom assays expertise,&nbsp;<a href=\"\/turn-key-discovery-labs\/\"><strong>Dalriada Discovery Labs<\/strong><\/a>&nbsp;can experimentally support the most complex hit-to-lead programs. Our&nbsp;<a href=\"\/turn-key-discovery-strategy\/\"><strong>Discovery Strategy<\/strong><\/a>&nbsp;team will support the design and oversight of the program to be conducted within&nbsp;<a href=\"\/turn-key-discovery-labs\/\"><strong>Discovery Labs<\/strong><\/a>&nbsp;or sub-contracted, if required, via&nbsp;<a href=\"\/turn-key-discovery-management\/\"><strong>Discovery Management<\/strong><\/a>.<\/p>\n<p><a href=\"\/turn-key-model\/\"><strong>Learn more about our Turn-Key model here<\/strong><\/a>.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Concept to PDC Discovery Programs Drug Discovery Services &nbsp; Hit to Lead Hit to Lead (H2L) is the process of optimizing validated hits to demonstrate they have the potential to become lead compounds and eventually a pre-clinical candidate. A series suitable to progress into lead optimization should demonstrate: The compound is clearly on target and [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":1233,"menu_order":93,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"folder":[],"_links":{"self":[{"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/pages\/1248"}],"collection":[{"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/comments?post=1248"}],"version-history":[{"count":7,"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/pages\/1248\/revisions"}],"predecessor-version":[{"id":7735,"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/pages\/1248\/revisions\/7735"}],"up":[{"embeddable":true,"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/pages\/1233"}],"wp:attachment":[{"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/media?parent=1248"}],"wp:term":[{"taxonomy":"folder","embeddable":true,"href":"https:\/\/dalriadatx.com\/wp-json\/wp\/v2\/folder?post=1248"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}